Variations in the reported incidence of ventilator-associated barotrauma may relate to differences in the patients’ underlying disease. Barotrauma was also associated with a significant increased in the ICU length of stay and mortality.īarotrauma is a feared complication of mechanical ventilation and is associated with increased morbidity and mortality. In a cohort of patients in whom airway pressures and tidal volume are limited, barotrauma is more likely in patients ventilated due to underlying lung disease (acute or chronic). Case-control analysis showed increased mortality in patients with barotrauma (51.4 vs 39.2% p=0.04) and prolonged ICU stay. Logistic regression analysis identified as factors independently associated with barotrauma: asthma, ILD ARDS as primary reason for mechanical ventilation and ARDS as a complication during the course of mechanical ventilation. Patients with and without barotrauma did not differ in any ventilator parameter. The incidence varied according to the reason for mechanical ventilation: 2.9% of patients with chronic obstructive pulmonary disease 6.3% of patients with asthma 10.0% of patients with chronic interstitial lung disease (ILD) 6.5% of patients with acute respiratory distress syndrome (ARDS) and 4.2% of patients with pneumonia. Barotrauma was present in 154 patients (2.9%). Measurements and resultsīaseline demographic data, primary indication for mechanical ventilation, daily ventilator settings, multiple-organ failure over the course of mechanical ventilation and outcome were collected. Patients and participantsĪ total of 5183 patients mechanically ventilated for more than 12 h. Prospective cohort of 361 intensive care units from 20 countries. To determine the incidence, risk factors, and outcome of barotrauma in a cohort of mechanically ventilated patients where limited tidal volumes and airway pressures were used.
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